ABSTRACT: Phyllanthus niruri L
has been traditionally used by Indonesian people to treat cough. However,
scientific basic of using this plant as mucolytic agent is still less observed.
The aim of this research is to evaluate in vitro mucolytic activity of ethanol
extract of P. niruri against bovine bowels mucose. In vitro mucolytic activity
of P. niruri was tested through method as like as Haslinda (1999) and Setyawati
(2004). Ethanol extract of P. niruri at various concentrations 0,25; 0,5; 0,75;
1,0; and 1,25% b/v mixed with mucose solution 50% b/v in fosfat buffer pH 7.
The solution incubated at 37ºC during 30 minute. Solutions viscosity measured
by stormer viscometer and evaluated its fluid flow properties. Negative control
was mucosa solution without extract and positive control was asetilsistein.
Mucolytic activity was shown by a concentration of extract which decrease
viscosity of mucose solution. Ethanol extract of P. niruri had mucolytic
activity againts bovine bowels mucose which decrease viscocity of mucose.
However, statistically there was no difference between various concentrations
of ethanol extract to mucolytic activity. Ethanol extract of P. niruri at
concentrations 0,25; 0,5; and 0,75% in mucose solution had fluid flow
properties thiksotropi pseudoplastic and at concentrations 1,0 and 1,25% had
fluid flow properties pseudoplastic.
Penulis: Yulias ninik
windriyati, Mimik murrukmihadi, Nissa ratna junita
Kode Jurnal: jpfarmasidd070009
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