ABSTRACT: The mangrove plant
have been long used the people for traditional medicine to cure various
diseases, one of them to cancer therapy. Investigation the anticancer potent of
R. mucronata has not been carried yet. This research was aimed to toxicity test
of R. mucronta leaves extracts againts Artemia salina Leach, then cytotoxicity
test of R. mucronata leave extracts againts Myeloma cancer cells. The
extraction of R. mucronata leaves was peformed by maseration with ethanol. The
ethanol extracts was partitioned with chloroform, ethylacetate and methanol.
The ethanol extracts of R. mucronata leaves respectively was examined their
toxicity againts A. salina Leach larv. The toxic exctracts was examined their
citotoxicity againts Myeloma cells. The ethanol extract of R. mucronata leaves
has toxic character because has LC50 < 1000 mg/mL. Citotoxicity test againts
Myeloma cells showed that the chloroform fraction of ethanol extract of R.
mucronata leaves have a high activity against Myeloma cell, LC50 value equal to
28,72 mg/mL. Phytochemical study showed that the active fractions contained
terpenoid and alkaloid.
Keywords: R. mucronata,
anticancer, Myeloma cells
Penulis: Hartiwi Diastuti,
Warsinah, Purwati
Kode Jurnal: jpkimiadd080016
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