ABSTRACT: Mangrove vegetation
especially tanjang (Bruguiera gymnorhiza) known as a kind of plant that used as
an ingredients for traditional medicine. Bioactive compound in tanjang bark has
potential medical. Although there is no previous experiment about tanjang bark,
few compounds from Bruguiera genus has been experimented and has an activity as
an anti-cancer and anti-tumor. The purpose of this experiment is to conduct
sitotoxicity tanjang bark against Meyloma cell. Tanjang bark sample that used
obtained from Tritih beach at Cilacap. Tanjang bark that has been cleaned and
dried is cut and then crused until it obtain powder. The powder is been
maceration with 96% ethanol and been evaporation. The extract that obtain is
used in sitotoxicity test using MTT (3-(4,5-dimethylthiazoil-2-il)-2,5-diphenil
tetrazolium bromide) method toward Meyloma cell after 24 hour of incubation
using several concentration variation. Tanjang bark extract in ethanol has LC50
value 508.19 mg/ml. Morphology analyze and nuclear staining shows that there is
apoptosis activity even in small amount. The result shows that tanjang bark
extract has a potency as an anti-cancer toward Meyloma cell.
Keywords: Bruguiera
gymnorhiza, antiproliferatif, myeloma
Penulis: Warsinah, Puji Lestari,
Trisnowati
Kode Jurnal: jpkimiadd070022
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