Pengaruh Pemberian Kombinasi Vitamin E dan Vitamin C sebagai Tindakan Preventif terhadap Jumlah Sel Leydig Mencit (Mus musculus) yang dipapar Boraks
Abstract: The aim of this
research was to investigate the effect of vitamin E and C combination as
preventive measure on Leydig cells number in mice (Mus musculus) treated with
borax. Twenty fve male micesof BALB/c strain divided into fve groups; P1 (vitamin
control) was given 28 mg/Kg /day of vitamin C solution combinated 105 mg/Kg/day
of vitamin E solution, P2 (borax control) was given 260 mg/Kg/day of borax, P3
was given combination of 28 mg/Kg/day vitamin C and 105 mg/Kg/day vitamin E solutions
and 260 mg/Kg/ day of boraks, P4 was given combination of 56 mg/Kg /dayof
vitamin C and 210 mg/Kg/day of vitamin E solutions and 260 mg/Kg/day of borax,
P5 was given combination of 112 mg/Kg/day of vitamin C and 420 mg/Kg/day of
vitamin E solutions and 260 mg/Kg/day of borax. Borax solution on P3, P4 and P5
groups treated in an hour after each groups treated with combination of vitamin
C and E solutions. The treatment were given by oral gavage for 14 days. The
result indicated there was asignifcant difference (P< 0.05) between P1
(vitamin control) and P2 (boraks control) group. Signifcant difference also
shown on P2 (boraks control) with P3, P4, P5 groups. There was indicated that combination of
vitamin C and vitamin E increased the number of normal Leydig cell of mice (Mus
musculus) treated with borax.
Keywords: Vitamin E, Vitamin
C, Leydig cell, mice, borax
Penulis: Citra Ayu Pramesti,
Arimbi, Pudji Srianto
Kode Jurnal: jppeternakandd160284
