Chemical Composition, Antimicrobial, Cytotoxic and Antiplasmodial Activities of Three Sponges from Buton Islands, Indonesia
Abstract: GC-MS analysis of
the crude extracts of three different species of Indonesian marine sponges has
been carried out for identification of bioactive compounds. The GC-MS analysis
from Haliclona (Gellius) sp., Lamellodysidea herbacea, and Spheciospongia
inconstans revealed the presence of 23, 21, 19 various compounds, respectively
and mainly sterols and fatty acids. All the sponge species has been evaluated
for antimicrobial activities, cytotoxicity using brine shrimp lethality
bioassay and heme polymerization inhibitory activity assay for antiplasmodial
activity. In this study, all the sponge species showed antimicrobial activities
against at leastone of the test strains. Among them, the extract of sponge
Lamellodysidea herbacea displayed activity against two Gram-positive bacteria
(S. aureus and B. subtilis) and the Gram-negative bacteria V. cholerae, with
inhibition zones of 10.3, 9.2 and 9.5 mm, respectively. The sponge Haliclona
(Gellius) sp., showed significant activity against fungal pathogen C. albicans.
The sponge Haliclona (Gellius) sp., displayed the ability to inhibit heme
polymerization indicating an anti-Plasmodium function and also showed potent
cytotoxic activity against the brine shrimp Artemia sp.
Keywords: GC-MS analysis,
antimicrobial, sponges,bioactive
Author: Masteria Yunovilsa
Putra, Tri Aryono Hadi
Journal Code: jpperikanangg170043