CYTOTOXIC ACTIVITY OF APORPHINE ALKALOIDS FROM ALSEODAPHNE PEDUNCULARIS (WALL. EX. NESS) MEISSN AGAINST HELA CELL LINE
Abstract: Genus of Alseodaphne
has been known as a source of apoprhine alkaloid that displayed potent cytotoxic
activities against selected cell lines. Two aporphine alkaloids, Corydine 1 and
norlirioferine 2 were isolated from leaves of Alseodaphne peduncularis (Wall.
Ex. Ness) Meissn. (Lauraceae). Phytochemical study involved extraction,
separation and purification byusing various chromatography methods and
structural elucidation by using spectoscopic techniques such as UV, IR LC-MS
and 1D and 2D NMR. These compounds were then assayed for cytotoxicity against
human uteric cervical tumor (heLa) and compare for safety with normal mouse
fibroblast (NIH/3T3) cell lines by using the MTT assay. Compound 2 displayed
potent cytotoxic activities against heLa cell, but compound 1 showed as
inactive. Both compounds have no significant effect against NIH/3T3 cell lines
indicated good for cancer agent treatment.
Penulis: Ulil Amna, Kartini
Ahmad and Mohd Azlan Nafiah
Kode Jurnal: jptlisetrodd150784
