The Role of Neutrophyl Lymphocyte Count Ratio as an Inflammatory Marker in Systemic Lupus Erythematosus
ABSTRACT: to evaluate
neutrophyl lymphocyte count ratio (NLCR) as an inflammatory marker in systemic
lupus erythematosus (SLE). Methods: this was a cross sectional study involving
21 SLE patients with mild and moderate disease activity according to Mex SLEDAI
score and 30 normal subjects. White blood cells counts were examined with
Sysmex XE-5000. The absolute neutrophyl count and absolute lymphocyte count
were tabulated and compared between SLE and normal subjects using unpaired
t-test. The comparison of NLCR between SLE and normal subject was calculated
using Mann-Whitney test. This study was conducted in the Department of Internal
Medicine Hasan Sadikin Hospital from November 2011 until January 2012. Results:
there was no signifcant difference in absolute neutrophyl count between SLE and
normal subjects (4158+1517 vs 4031+1218 /mm3, p=0.74). The absolute lymphocyte
count was signifcantly lower in SLE than normal subjects (1721+600 vs
2397+587/mm3, p=0.000). NLCR was signifcantly higher in SLE than normal
subjects (2.52 (1.01-10.92) vs 1.65 (0.77-4.59), p=0.007). There was no
signifcant difference in NLCR between SLE with mild and moderate activity (2.59
(1.01-10.92) vs 2.01 (1.38-3.98), p= 0.412). Based on ROC curve, with AUC
0.727, cut off NLCR value >1.93 had 70% sensitivity and 67% specifcity in
differentiating between SLE and normal subjects. Conclusion: NLCR could be used
as simple inflammatory parameter in SLE.
Key words: neutrophyl
lymphocyte count ratio (NLCR), systemic lupus erythematosus (SLE), inflammatory marker
Author: Amaylia Oehadian,
Hendarsyah Suryadinata, Sumartini Dewi, Riardi Pramudyo, Bachti Alisjahbana
Journal Code: jpkedokterangg130261
