The effects of the ethanolic extract of mahogany seeds (Swietenia macrophylla King) on the renal function of streptozotocin-induced diabetic rats
Abstract: Diabetes-associated
oxidative stress causes glomerular hypertrophy, decrease of glomerular
filtration rate and inhibits cell proliferation that lead to the decrease of
renalfunction as indiated by the increase of serum creatinine level and the
presence of protein in urine. Mahogany seed (Swietenia macrophylla King) has
been proven to have antidiabetic activity. This study was conducted to evaluate
the effect of the ethanolic extract of mahogany seeds on the renal function of
streptozotocin-induced diabetic rats. Six normal rats as control (Group I) and
24 diabetic rats were used in this study. The diabetic rats were randomized
allocated into four groups with six rats in each group. Group II was considered
as diabetic rats control and received aquadest. Group III-V wereconsidered as
extract administered diabetic group and received ethanolic extract of S. macrophylla
seed for 21 days at a dose of 50, 100 and 200 mg/kg BW, respectively. Serum
malondialdehyde (MDA), serum creatinine, and urine protein levels were
monitored, before and after the ethanolic extract of S. macrophylla seed
administration. Serum MDA, serum creatinine and urine protein levels of all
rats after STZ induction (Group II-V) were significantly higher than without
STZ induction (p < 0.05). A significant decrease in the serum MDA and serum
creatinine as well as urine protein levels were observed after the treatment
with ethanolic extract of S. macrophylla seed compared to before treatment (p
< 0.05). In conclusion, the ethanolic extract of S. macrophylla seed is able
to correct renal dysfunction of streptozotocin-induced diabetic rats.
Author: Lukman La Basy, Sri
Lestari SR, Sri Kadarsih
Journal Code: jpkedokterangg150360
