The Effectiveness of a Three Day Course Antibiotic Posturodynamic Study in Preventing Lower Urinary Tract Infection
ABSTRACT: to evaluate the
effect of a 3-day course antibiotic post-urodynamic study (UDS) to prevent
urinary tract infection (UTI). Methods: this was a randomized double blind
clinical trial on the proportion of UTI in patients who received levofloxacin
500 mg once a day for 3 days after UDS compared to nontreated patients. The outcome
of this study was the incidence of lower UTI in levofloxacin group and placebo
group. Lower UTI was defned as patient with one or more clinical symptoms of
lower UTI and one or more urinalysis parameter of UTI. Chi-square was used to
evaluate the association between the lower UTI and treatment group. Results: a
total of 126 patients were enrolled in this study from two outpatient urology
clinics in Jakarta: Cipto Mangunkusumo Hospital and Asri Hospital. Overall, 26
patients (20.6%) had UTI post UDS (8 out of 63 patients from levofloxacin arm
(12.7%) and 18 out of 63 patients from placebo arm (28.6%); p=0.028). The most
common isolate found was E. coli (n=18 patients; 69.2%). The most common
indications to perform UDS were Lower Urinary Tract Symptoms (LUTS) with
failure of therapy (n=43 patients; 25%), LUTS after invasive treatment (n=29
patients; 16.9%), and overactive bladder with failure of therapy (n=22
patients; 12.7%). Conclusion: the use of antibiotic post-UDS can prevent incidence
of lower UTI.
Author: Harrina E. Rahardjo,
Pande M.W. Tirtayasa, Andika Afriansyah, Dyandra Parikesit, Muhammad I. Akbar
Journal Code: jpkedokterangg160015
