The Effect of High Poly Unsaturated Fatty Acid (PUFA) Dietary Supplementation on Inflammatory Status of Patients with Advanced Cervical Cancer on Radiation Treatment
ABSTRACT: to identify the
effect of high-PUFA dietary supplementation on inflammatory status of patients
with advanced cervical cancer. Methods: a randomized double-blind clinical
trial was conducted in patients with advanced cervical cancer who had undergone
external radiation therapy at Department of Radiotherapy, Cipto Mangunkusumo
Hospital, Jakarta, between April 2013 and April 2014. The inflammatory status
was evaluated based on serum prostaglandin E2 (PGE2) levels using ELISA method.
The dietary supplementation was isocaloric, isoprotein and contained PUFA with
a ratio of ω-6: ω-3 fatty acid = 1.27:1 and supplementation without PUFA. Data
were analyzed with statistical tests, including Shapiro-Wilk test, independent
T-test and Mann–Whitney test. Results: there was statistically no signifcant
difference on PGE2 level between treatment and control groups (p=0.127).
However, there was clinically signifcant difference, in which the treatment
group had reduced PGE2 level by 8.9%; while the control group had increased
level by 28.1%. Conclusion: dietary supplementation enriched with PUFA can
reduce inflammatory status in patients with advanced cervical cancer. Reduced
PGE 2 level will lower the survival of cancer cells; therefore dietary supplementation
enriched with PUFA with a ratio of ω-6 : ω-3 fatty acid = 1.27 : 1 along with
radiation therapy may improve tumor response to radiation.
Author: Sri Wuryanti4,
Andrijono, Susworo, Fiastuti Witjaksono
Journal Code: jpkedokterangg150256
