ST2 Levels Before and After Treatment of NYHA III and IV Heart Failure
ABSTRACT: to fnd whether ST2
can be used to determine clinical improvement in patients with NYHA III and IV heart
failure. Methods: this is a longitudinal, pre and post-test study without a
control group. Study subjects are 23 NYHA III and IV heart failure patients.
ST2 was tested at the start and end of hospital treatment. Results: of 23 heart
failure patients, 70% were classifed as NYHA III while 30% were NYHA IV. There
were more male subjects than females (51.4% vs. 48.6%). Median age for NYHA III
heart failure patients was 52 years and mean age for NYHA IV heart failure
patients was 58 years. Heart failure was mostly caused by coronary artery
disease (52%). ST2 levels did not correlate with age, length of care, sex and
cause of heart failure. ST2 levels in NYHA IV heart failure patients
(58.82±37.36 ng/mL) tended to be higher than the one in NYHA III group (30.75
[14.4-84.5] ng/mL), but the difference was statistically not insignifcant
(p=0.89). ST2 levels at the start of treatment was signifcantly higher than at
the end (31.4 [14-129.2] ng/mL vs. 18.4 [7.6-77.8] ng/mL), p=0.001. This shows
that clinical improvement is associated with signifcant reduction of ST2
levels. Conclusion: ST2 can be used as a marker to determine clinical
improvement in NYHA III and IV heart failure.
Author: Suzanna Immanuel,
Neila Mona AG. Mandey, Lukman H. Makmun
Journal Code: jpkedokterangg150236
