Serum Selenium Concentration in Cervical Cancer Patients: Preliminary Study and Literature Review
Abstract: To analyze the role
of selenium and glutathione peroxidase (GPx) in cervical cancer.
Methods: Serum selenium concentrations and GPx activities of 19 women
with cervical cancer along with their healthy counterparts (control group) were
obtained. Selenium concentration were measured fluorometrically and GPx
activities were measured spectrophotometrically based on the quantity of NADPH
used in the reduction of glutathione.
Results: The mean of serum selenium concentrations in cervical cancer
group was significantly lower than that in the control group, 67.24±15 ng/mL
and 77.05±12 ng/mL (p=0.03), respectively. The mean GPx activity in the
cervical cancer group was also significantly lower than that in the control
group, 128.18±38 ∆mmol NADPH/min/L and 148.9±23 ∆mmol NADPH/min/L (p=0.04),
respectively. Multivariate analysis in the cervical cancer patients showed that
the Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) staging
score (early vs. advanced) was inversely correlated with serum selenium
concentration (p=0.027).
Conclusions: Serum selenium concentration and GPx activity was
significantly lower in the cervical cancer patients. Our results demonstrate
that selenium and GPx activity may have an important role in the carcinogenesis
of cervical cancer.
Author: Leri Septiani, Yudi
Mulyana Hidayat, Mutakin, Rizky Abdulah, Ahmad Faried, Hiroshi Koyama
Journal Code: jpkedokterangg160122