Serum Matrix Metalloproteinase-9 Levels in Acute Coronary Syndrome Patients with and without Hyperglycemia
ABSTRACT: to determine the
difference in serum matrix metalloproteinase-9 (MMP-9) levels among acute
coronary syndrome patients with and without hyperglycemia. Methods: this study
was a cross-sectional study on patients with acute coronary syndrome admitted
to ICCU of Dr.Sardjito Hospital Yogyakarta Indonesia. Measurements of blood
glucose level were performed on hospital admission, while measurement of MMP-9
level was performed upon arrival at the ICCU. Hyperglycemia was defned as a
random blood glucose level of >140 mg/dL. Student’s t test was performed to
analyze the difference of MMP-9 level between subjects with and without
hyperglycemia. Results: of 72 enrolled subjects, there were 34 subjects with
hyperglycemia and 38 subjects without hyperglycemia. The mean blood glucose
level was signifcantly different in subjects with hyperglycemia as compared to
those without hyperglycemia (204.4±92.16 vs. 108.93±19.1 mg/dL, p=0.0001). The
mean MMP-9 level in subjects with hyperglycemia was signifcantly higher than
those without hyperglycemia (1574±573.61 vs. 1370±573.66 ng/mL, p=0.025). The
prevalence ratio of high MMP-9 level among subjects with hyperglycemia was 2.88
(95% CI: 1.16-7.14), p=0.004. Conclusion: serum MMP-9 level in patients
suffering from acute coronary syndrome with hyperglycemia was signifcantly
higher than those without hyperglycemia.
Author: Budi Y. Setianto, Agus
F. Achmad, Luthfan B. Purnomo
Journal Code: jpkedokterangg140272
