Role of oxidative stress on acute ischaemic stroke
Abstract: After the onset of a
stroke, blood flows disrupted in areas affected by vascular occlusion limit the
delivery of oxygen and metabolic substrates to neurons causing ATP reduction
and energy depletion. The glucose and oxygen deficit that occurs after severe
vascular occlusion is the origin of the mechanisms that lead to cell death and
cerebral injury caused of oxidative stress. Oxidative stress constitutes
mechanism of injury of many types of disease processes. On oxidative stress
occurs on the increase in ROS and RNS. This paper will discuss about cerebral
ischemia that causes activation of ROS and RNS, also themechanisms that play a
role in cell death after cerebral ischemia, for example the role of
phospholipase, Haber-Weiss reaction, and lipid peroxidation. It is also
described about anti-oxidants to fight free radicals, for examples glutathione
peroxidase, catalase and superoxide dismutase.
Author: Ismail Setyopranot
Journal Code: jpkedokterangg160170