Risk factors of sepsis after open congenital cardiac surgery in infants: a pilot study
Abstract: Postsurgical sepsis
is one of the main causes of the high mortality and morbidity after open
congenital heart surgery in infants.
This study aimed to evaluate the role of cardiopulmonary bypass
duration, thymectomy, surgical complexity, and nutritional status on
postsurgical sepsis after open congenital cardiac surgery in infants.
Methods: A total of 40 patients <1 year of age with congenital heart
disease, Aristotle Basic Score (ABS) ≥6 were followed for clinical and
laboratory data before and after surgery until the occurrence of signs or
symptoms of sepsis or until a maximum of 7 days after surgery. Bivariate
analyses were performed. Variables with p≤0.200 were then included for logistic
regression.
Results: Duration of cardiopulmonary bypass ≥90 minutes was associated
with 5.538 increased risk of postsurgical sepsis in comparison to those ≤90
minutes (80% vs 25%, RR=5.538, p=0.006). No association was observed between
the incidence of postsurgical sepsis with poor nutritional status (86% vs 84%,
RR=1.059, p=1.000), thymectomy (and 50% vs 76%, RR=0.481, p=0.157), and
Aristotle Basic Score (p=0.870).
Conclusion: Cardiopulmonary bypass time influences the incidence of
sepsis infants undergoing open congenital cardiac surgery. Further studies are
needed to elaborate a number of risk factors associated with the incidence of
sepsis in this population.
Keywords: aortic cross-clamp;
Aristotle Basic Score; cardiopulmonary bypass; congenital heart disease;
nutritional status; sepsis
Author: Dicky Fakhri, Pribadi
W. Busro, Budi Rahmat, Salomo Purba, Aryo A.P. Mukti, Michael Caesario, Kelly
Christy, Anwar Santoso, Samsuridjal Djauzi
Journal Code: jpkedokterangg160158
