Risk factors for mortality in children with Wilms tumor
Abstract: Wilms tumor is the
most common renal malignancy in children (95%) and one of the leading causes of
death in children, with high mortality rates in developing countries.
Identifying risk factors for mortality is important in order to provide early
intervention to improve cure rates.
Objective To identify risk factors for mortality in children with Wilms
tumor.
Methods We performed a case-control study of children (0-18 years of age)
with Wilms tumor admitted to Dr. Sardjito Hospital between 2005 and 2012. The
case group consisted of children who died of Wilms tumor, whereas the control
group were children who survived. Data were collected from medical records.
Statistical analyses using Chi-square and logistic regression tests were done
to determine odds ratios and 95% CI of the potential risk factors for mortality
from Wilms tumor.
Results Thirty-five children with Wilms tumor were admitted to Dr.
Sardjito Hospital during the study period. Nine (26%) children died and 26
survived. Stage ≥III was a significant risk factor for mortality in chidren
with Wilms tumor (OR 62.8; 95%CI 5.6 to 70.5). Age ≥2 years (OR 1.4; 95%CI 0.1
to 14.3) and male sex (OR 1.2; 95%CI 0.1 to 10.8) were not significant risk
factors for mortality.
Conclusion Stage ≥III is a risk factor for mortality in children with
Wilms tumor.
Author: Yuni Purwanti, Sutaryo
Sutaryo, Sri Mulatsih, Pungky Ardani Kusuma
Journal Code: jpkedokterangg160115