Renal evaluation in patients with type 2 diabetes mellitus and its association with diastolic blood pressure
Abstract: HbA1c is correlated
with the estimated glomerular filtration rate (eGFR) and diastolic blood
pressure (DBP). Our main objective was to evaluate the trend of biochemical and
clinical variables, in relation to the eGFR in patients with type 2 diabetes
mellitus (T2DM).
Methods: This was a retrospective, longitudinal, and descriptive study,
including patients with T2DM, who were cared for from January 2014 until
December 2014, at the ClĂnica de Diabetes, Hospital Regional “Gral. Ignacio
Zaragoza", ISSSTE, Mexico City, Mexico. eGFR was calculated using three
formulas: the chronic kidney disease – epidemiology collaboration (CKD-EPI),
Cockcroft-Gault, and modification of diet in renal disease (MDRD), during two
periods of observation, 3 and 6 months. The results were compared by Student t
tests or Wilcoxon-Mann-Whitney test depending on the variable distribution.
Pearson correlation was employed to determine the relation between the eGFR determined
with each formula and the analyzed variables.
Results: The mean age was 56.5±11.3 years in the group of 3 months’
follow-up (n=110) and 57.1±13.8 years in the group of 6 months’ follow-up
(n=47). In both groups, the formula with the lowest percentages of cases of CKD
was CKD-EPI and the difference of this formula had a basal and final
significant positive correlation with the DBP.
Conclusion: The CKD-EPI formula showed the lowest percentages of cases of
CKD in a short follow-up period, and its difference is consistently associated
with the DBP, confirming the importance of controlling the later to mitigate
the evolution to CKD.
Author: Fokine D. Anna,
Mendieta Z. Hugo, Mendieta A.M. Ruth
Journal Code: jpkedokterangg160146