Relationship between Metformin and Frailty Syndrome in Elderly People with Type 2 Diabetes
ABSTRACT: to explore the
possibility of metformin protective effect on frailty syndrome. Methods: this
was a case control study conducted in subjects’ ≥60 years old who visited the
Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National
Referral Hospital between March and June 2013. Diagnosis of frailty was established
using the FI-40 item criteria. Statistical analysis was done with chi-square
method for bivariate and logistic regression method in multivariate analysis,
all data was accompanied with 95% confdence interval. Results: frailty syndrome
was found in 25% of subjects (n=59), with median age of 72 years old (SD 6.27)
and median of FI-40 item score was 0.18 (SD 0.085). Metformin was found to have
a signifcant relationship with frailty syndrome in the elderly diabetics, which
retained signifcant value after multivariate analysis (adjusted OR 0.043; 95%
CI 0.019-0.099; p<0.001). Conclusion: metformin was shown to have protective
effect against frailty syndrome in elderly diabetics.
Author: Stevent Sumantri, Siti
Setiati, Dyah Purnamasari, Esthika Dewiasty
Journal Code: jpkedokterangg140280
