Quality of life in children with cancer and their normal siblings
Abstract: Background Cancer
treatment in children influences the quality of life of patients and their
families. The Pediatric Quality of Life (PedsQL) inventory is a questionnaire
to assess quality of life of the healthy and ill children. Objective To compare
quality of life in children with cancer and their normal siblings, and to
compare quality of life in those with hematologic malignancies to those with
solid tumors. Methods A cross-sectional study was conducted among 5-to-18-
year-olds at the Hematology-Oncology Division at Haji Adam Malik Hospital,
Medan, North Sumatera, from May to July 2012. The case group (subjects with
cancer) filled the PedsQL 3.0 and 4.0 questionnaires, while the control group
(normal siblings) filled only the PedsQL 4.0 questionnaire. Independent T-test
was used to compare the quality of life between children with cancer and their
normal siblings. Results There were 46 children in each group. The PedsQL 4.0
results in children with cancer and their normal siblings, and PedsQL 3.0
between hematology malignant and solid cancer were as follows: physical
function 36.9 vs. 80.7, respectively (95%CI of differences -52.639 to -34.990;
P= 0.0001), emotional function 40.4 vs. 69.3, respectively (95%CI of
differences -35.912 to -21.914; P=0.0001), social function 71.5 vs. 93.9,
respectively (95%CI of differences - 29.238 to -15.587; P=0.0001), school
function 20.7 vs. 74.2, respectively (95%CI of differences - 62.124 to -44.832;
P=0.0001), and total score 42.1 vs. 79.3, respectively (95%CI of differences -
43.066 to -31.344; P=0.0001). School function was the most affected parameter
in children with cancer compared to their normal siblings. Conclusion There is
a significant difference in quality of life between children with cancer and
their normal siblings, for all four parameters examined by the PedsQL
inventory. However, there are no significant differences in quality of life
between children with hematologic malignancy and those with solid cancer.
Author: Hilda, Bidasari Lubis,
Hakimi, Olga Rasiyanti Siregar
Journal Code: jpkedokterangg150261
