Prothrombine and activated partial thromboplastin time are prolonged in hepatic cirrhosis
Abstract: Chronic hepatitis
and hepatic cirrhosis are chronic liver diseases that cause disorders of liver
function, such as the formation of platelets and coagulation factors
(prothrombin time/PT and activated partial thromboplastin time/APTT). Chronic
hepatitis in the long term can develop into hepatic cirrhosis. The aim of this
study was to determine platelet count, PT, and APTT as indicators in the
progression of chronic hepatitis towards hepatic cirrhosis.
A cross-sectional study was conducted on 50 patients with chronic
hepatitis and hepatic cirrhosis in Semarang City Regional General Hospital,
Telogorejo Hospital and Kariadi General Hospital. The platelet count was
measured with a Sysmex XP-100, while PT and APTT was measured with a Sysmex
CA-1500 coagulometer. The Mann Whitney test was applied to analyze the
difference in platelet count, PT, and APTT between chronic hepatitis and
hepatic cirrhosis.
Median, minimum, and maximum values of platelet count, PT and APTT in
chronic hepatitis were 284.000/µl, 210.000/µl, 390.000/µl; 10.6 sec, 9.5 sec,
13.6 sec; and 30.5 sec, 24.2 sec, 46.4 sec, respectively, and in hepatic
cirrhosis they were 96.300/µl, 48.200/µl, 133.800/µl; 27.5 sec, 11.9 sec, 44.7
sec; and 55.6 sec, 31.3 sec, 72.0 sec, respectively. There was a significant
difference the reduction of platelet count, and the prolongation of PT and APTT
in chronic hepatitis compared to hepatic cirrhosis (p=0.000).
Prothrombine time and APTT were prolonged and platelet count was
decreased in hepatic cirrhosis subjects. The three parameters may be used to
evaluate the progression of chronic hepatitis towards hepatic cirrhosis.
Author: Edward Kurnia Setiawan
Limijadi, Lisyani Budi Suromo, Imam Budiwiyono
Journal Code: jpkedokterangg160051
