Prognostic factors for mortality in pediatric acute poststreptococcal glomerulonephritis
Abstract: Acute
post-streptococcal glomerulonephritis (APSGN) is one of the most common causes
of glomerular disease in developing countries, including Indonesia. It can lead
to end stage renal failure and higher mortality rates. To decrease morbidity
and mortality, it is important to understand the prognostic factors affecting
the disease.
Objective To identify prognostic factors affecting outcomes in pediatric
APSGN patients.
Methods Study data were collected from medical records of patients with
APSGN hospitalized in Wahidin Sudirohusodo Hospital, Makassar in 2009-2013.
Possible prognotic factors analyzed were gender, age, nutritional status, level
of consciousness, as well as proteinuria, hemoglobin, serum albumin, urea, and
creatinine levels.
Results Of 86 subjects, 82 (95.3%) survived and 4 (4.7%) died.
Fifty-three (61.6%) patients were male and 33 (38.4%) were female. Subjects’
ages ranged from 3.42 to 14.67 years, with a mean age of 9.36 years.
Multivariate analysis revealed serum creatinine level >1.5 mg/dL to be an
independent prognostic factor for mortality in children with APSGN (AOR 15.43;
95%CI 1.31 to 181.7; P=0.03).
Conclusion High serum creatinine level is an independent prognostic
factor for poor outcomes in children with APSGN.
Author: Syamsul Nur, Husein
Albar, Dasril Daud
Journal Code: jpkedokterangg160059
