Prevalence and clinical characteristics of rotavirus diarrhea in Mataram, Lombok, Indonesia
Abstract: Rotavirus is the
most common cause of severe diarrhea and dehydration among children aged <5
years in developed and developing countries, including Indonesia. There have
been few studies on the prevalence of rotavirus diarrhea in Mataram.
Objective To determine the prevalence and characteristics of rotavirus
diarrhea in children under five years of age with acute diarrhea in Mataram.
Methods A cross sectional study using the WHO Generic Protocol for
Rotavirus Surveillance was conducted in the Nusa Tenggara Barat (NTB) General
Hospital, Mataram, as part of a multicenter study by the Indonesian Rotavirus
Surveillance Network (IRSN) for children under five years of age. Subjects were
diagnosed with rotavirus diarrhea based on stool sample examinations, using
RT-PCR for genotyping. They were admitted to the Pediatrics Ward of the NTB
Provincial General Hospital from January to December 2010.
Results Of 329 children admitted with acute diarrhea, 210 (63.8%) had
rotavirus positive stool specimens. For the year 2010, the highest incidence of
rotavirus infection was in the month of January (86.4%). Rotavirus infections
were found in children less than 2 years of age (65.4%), with the highest
prevalence in the age group of 6 to 23 months (68.5%). In addition to clinical
symptoms of watery diarrhea, there was a significantly greater percentage of
vomiting in rotaviral vs. non-rotaviral diarrhea (67.7% vs. 32.3%,
respectively; P<0.05). The majority of G and P genotypes found were G1
(86%), G2 (12%), P[8] (66%), P[4] (12.8%), and P[6] (8%).
Conclusion Rotavirus infections are the most common cause of acute
diarrhea in children aged <2 years in Mataram, Indonesia.
Author: Wayan Sulaksmana
Sandhi Parwata, Wayan Sukardi, Abdul Wahab, Yati Soenarto
Journal Code: jpkedokterangg160038
