Plasma Sodium in Relation with the Extracellular Fluid Volume in Chronic Hemodialysis Patients
ABSTRACT: to obtain a causal
relationship between changes in plasma sodium levels and increased
extracellular fluid volume between post-hemodialysis and pre-hemodialysis on the
following day or plasma sodium serves as a predictor of extracellular fluid
volume. Methods: the study was conducted on 40 subjects randomly selected from
the 247 chronic hemodialysis patients in Hemodialysis Unit of Nephrology and
Hypertension Division, Department of Internal Medicine, Faculty of Medicine
Universitas Indonesia - Cipto Mangunkusumo Hospital that met the inclusion and
exclusion criteria. Their plasma sodium levels, post-hemodialysis weight and
prehemodialysis weight on the following day were examined. Results: There was
no signifcant difference in the plasma sodium levels between post-hemodialysis
and pre-hemodialysis on the following day. However, there was a considerable
differences between post-hemodialysis weight and pre-hemodialysis weight on the
following day (p = 0.0000). In regression analysis that were conducted on the
relationship between the difference in prehemodialysis sodium levels subtracted
by previous post-hemodiaysis sodium levels (Y) and the difference in pre-hemodialysis
weight subtractted by previous post-hemodialysis weight (X), a signifcant
causal relationship was found with the regression formula of Y = - 2.205 +
0.937 X. Conclusion: plasma sodium levels in chronic hemodialysis patients can
be used as predictors of body fluid volume or extracellular fluid volume. At each
dialysis unit, the recommended weight gain for the patients are 2.5 kg-2.9 kg,
in order to prevent a signifcant decrease in plasma sodium levels that could
lead to mortality.
Author: Parlindungan Siregar
Journal Code: jpkedokterangg140285
