Peripheral and Intracranial Compartment Serum Level of Selenium in Pediatric Patients with Intracranial Tumor in Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran–Dr. Hasan Sadikin Hospital, Bandung, Indonesia: a Preliminary Study and Literature Review
Abstract: To determine the
level of Selenium (Se) in peripheral and intracranial serum in pediatric
patients with intracranial tumor. Selenium has chemopreventive potentials and
acts as neuromodulator.
Methods: This study was conducted on 13 pediatric patients with
intracranial tumors who were treated in Dr. Hasan Sadikin Hospital, Bandung in
the period of February 2014 to February 2015. Samples were taken from
peripheral and intracranial serum. The results were analyzed with independent
t-test and Pearson correlation test. Significance is defined as p≤0.05 with 95%
confidence interval.
Results: The results showed that the average Se concentration in
peripheral serum was significantly higher than the Se concentration in
intracranial serum (95.92±20.95 μg/L and 66.62±22.37 μg/L, respectively). After
classifying the subjects into groups based on sex, age, tumor location, and
grades, the difference between Se concentrations were still statistically
significant (p≤0.05), with the exception of the supratentorial group
(p=0.0053). Pearson correlation test showed very-low to medium strength
correlations between peripheral and intracranial serum Se concentration in all
groups (r=0.16–0.59, p>0.05).
Conclusions: A significant difference is seen between the peripheral and
intracranial serum Se concentration means in pediatric patients with
intracranial tumors, with higher concentrations observed in the peripheral
serum. Further studies are required to investigate the roles of Se in the
management of pediatric patients with intracranial tumors.
Keywords: Pediatric
intracranial tumor patients, selenium concentration in peripheral and
intracranial serum
Author: Ahmad Faried,
Priandana Adya Eka Saputra, Mirna Sobana, Muhammad Zafrullah Arifin
Journal Code: jpkedokterangg160124