PERBANDINGAN IMUNOEKSPRESI P53 DAN CASPASE-3 PADA MOLA HIDATIDOSA PARSIAL, MOLA HIDATIDOSA KOMPLIT, DAN KORIOKARSINOMA
ABSTRACT: Partial hydatidiform
mole, complete hydatidiform mole and choriocarcinoma are gestational
trophoblastic diseases which have high incidence in Indonesia. Most complete
hydatidiform mole can transform into choriocarcinoma , but pathogenesis of the
transformation is remain unknown.
Apoptosis plays an important role in the pathogenesis of human malignancy. p53
and caspase - 3 play a role in apotosis . The aim of this study is to evaluate
the p53 and caspase-3 immunoexpression
in partial hydatidiform mole, complete hydatidiform mole and choriocarcinoma
Methods: This is an observational analytic cross sectional
study, conducted on 30 cases of gestational trophoblastic diseases
consisted of 10 cases of partial hydatidiform mole, 10 cases of complete
hydatidiform mole and 10 cases of choriocarcinoma. Immunohistochemical examination of p53 and Caspase-3 were performed on all cases.
Result : The result showed significant difference between the p53
immunoexpression in partial hydatidiform mole and choriocarcinoma (p = 0.002),
there was no significant p53 immunoexpression difference between complete
hydatidiform mole and choriocarcinoma (p
= 0.121), there was no caspase-3 immunoexpression difference between partial
hydatidiform mole and choriocarcinoma (p = 0.160) and there was no caspase-3
immunoexpression difference between complete hydatidiform mole and
choriocarcinoma (p = 0.361). p53
Immunoexpresion was higher in the case of complete hydatidiform mole and choriocarcinoma
but tend to be lower in partial hydatidiform mole.
Conclusion : In conclusion, p53 may play a role in the pathogenesis of
complete hydatidiform mole and choriocarcinoma, but has a lesser role in the
pathogenesis of partial hydatidiform mole. Caspase-3 might not play a role in
the pathogenesis of hydatidiform mole transformation into choriocarcinoma.
Penulis: Odilia Dos Reis,
Hasrayati Agustina, Abdul Hadi Hassan, Bethy S Hernowo
Kode Jurnal: jpkedokterandd140595
