PENGHAMBATAN KSANTIN OKSIDASE OLEH KOMBINASI EKSTRAK TEMPUYUNG (Sonchus Arvensis) DAN SALAM (Syzygium Polyanthum) PADA MENCIT HIPERURISEMIA
Abstract: Tempuyung (Sonchus
arvensis) and salam (Syzygium polyanthum) leaves can lower uric acid levels
were studied. The purpose of this research was to determine mechanism of
combined o f tempuyung and salam extracts to reduce uric acid levels by inhibiting
xanthine oxidase in hyperuricemic mice. This research used completely
randomized design using mice. Fifteen mice were made hiperuricemic by 250
mg/kgBW potassium oxonate p.o then the mice were divided into 3 groups. Group I
induced 10 mg/kgBW allopurinol p.o as positive control, group II induced
tempuyung-salam p.o each 100 mg/kgBW as the treatment group, group th III
induced 0.5 mL/20 gBW distilled water p.o as negative control. Liver was taken
4 day after 2 hours induced potassium oxonate. Data inhibition xanthine oxidase
activity was tested with Mann-Whitney. The result showed that the combination
of tempuyung-salam extract each 100 mg/kgBW could inhibit xanthine oxidase
activity of 51,16%±2,76%, while allopurinol 90,20%±0,16% (p = 0.000).
Penulis: Dr. Muhtadi, Idi
Retnani, Nurcahyanti Wahyuningtyas
Kode Jurnal: jpkedokterandd120218
