PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL
Abstract: The rind of rambutan
fruit (Nephelium lappaceum L.) has been reported to have a very strong
antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains avonoids and phenolic . This compounds are potentially as
hypolipidemic effect. This study aims to determine the hypolipidemic
effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain
male rats. This research method is the pre- and post-control group design. 25
rats were divided into 5 groups. Group I (negative control) were treated by a
solution of 0.5% CMC-Na, group II (positive control) were treatedby
cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of
ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg
respectively. hiperkolesterlemia induction is done by giving a high cholesterol
diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail
egg yolk, water, PTU and feed high cholesterol consisting of margarine and
standard feed. Treatment of mice was conducted for 2 weeks. The results showed
that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125,
250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ±
18.15%, and 60.75 ± 8, 26%.
Penulis: Muhtadi, Haryoto,
Tanti Azizah Sujono, Peni Indaryudha, Andi Suhendi
Kode Jurnal: jpkedokterandd130447