PELOD score, serum procalcitonin, and lactate levels in pediatric sepsis
Abstract: Sepsis remains a
major cause of morbidity and mortality among critically ill children in the
pediatric intensive care unit (PICU). Procalcitonin and lactate have been used
as biomarkers of sepsis, as they have been correlated with disease severity,
organ failure and death. The Pediatric Logistic Organ Dysfunction (PELOD) score
is a tool to assess the severity of organ dysfunction in critically ill
children. Objective To investigate the correlation between PELOD score and
procalcitonin and lactate levels in pediatric sepsis. ethods A cross-sectional study was conducted
in children with sepsis who were admitted to the PICU from April to July 2012.
Sepsis was defined as systemic inflammatory response yndrome (SIRS), as a result of suspected or
proven infection. Proven infection was defined as positive culture findings
(blood,mL. Spearman’s test was used to assess for correlations between PELOD
scores and procalcitonin as well as lactate levels. Results Thirty-two patients
were analyzed, consisting of 18 males and 14 females with an age range of 1-432
months (median 21 months). There was no statistically significant correlation
between procalcitonin level and PELOD score (r=- 0.186, 95%CI -0.502 to 0.174,
P=0.308) nor between lactate level(r=-0.069, 95%CI -0.408 to 0.287, P=0.709)
and PELOD score. Conclusion Serum procalcitonin and lactate levels are not correlated
with PELOD scores in children with sepsis
Author: Jufitriani Ismy, Munar
Lubis, Erna Mutiara, Gema Nazri Yani, Yunnie Trisnawati
Journal Code: jpkedokterangg150271