NCEP-ATP III and IDF criteria for metabolic syndrome predict type 2 diabetes mellitus
Abstract: Subjects with
metabolic syndrome (MetS) have a greater risk for acquiring type 2 diabetes
mellitus (type 2 DM). The MetS criteria usually used are those of the National
Cholesterol Education Program Expert Panel (NCEP) and Adult Treatment Panel III
(ATP III) and of the International Diabetes Federation (IDF). This study aimed
to evaluate the modified NCEP-ATP III and IDF criteria as predictor of type 2
DM among subjects with MetS.
A cohort study was conducted among 4240 subjects with MetS. MetS was
determined according to the modified NCEP-ATP III and IDF criteria. The study
followed up 3324 non-diabetic subjects of the cohort study of non-communicable
disease (NCD) risk factors (NCD study) during a 2-year period. Type 2 DM was
determined from the diagnosis by health personnel or from fasting blood glucose
of ≥126 mg/dL or blood glucose of ≥200 mg/dL, 2 hours after 75g glucose
loading.
The MetS prevalence based on modified NCEP ATP III and IDF criteria in
non-DM subjects was 17.1% and 15.6%, respectively. The risk for DM in subjects
with MetS using modified NCEP ATP III and IDF criteria was 4.7 (CI 95%:
3.4-6.5) and 4.1 (CI 95%: 3.0-5.7), respectively.
Both MetS criteria can be used as predictors of the occurrence of DM type
2, but the modified NCEP-ATP III is more properly applied than the IDF criteria
in subjects with MetS. Screening programs and routine monitoring of MetS
components are required for early detection of type 2 DM.
Keywords: Metabolic syndrome;
National Cholesterol Education Program Expert Panel and Adult Treatment Panel
III; type 2 diabetes mellitus
Author: Eva Sulistiowati,
Marice Sihombing
Journal Code: jpkedokterangg160039
