Microbiological profile and antimicrobial susceptibility in children with perforated appendicitis at Dr. Sardjito General Hospital, Yogyakarta
ABSTRACT: Acute appendicitis
is the most common surgical cause of acute abdominal pain in children. Perforated
appendicitis is the major complication of acute appendicitis with incidence in
children of 30-40%. Perforated appendicitis should be operated immediately
along with the administration of broad-spectrum antibiotics. The aim of this
study isto analyze the microbiological profle and determine the antimicrobial
susceptibility in children with perforated appendicitis at Dr. Sardjito General
Hospital, Yogyakarta, Indonesia.We analyzed the pus from the perforated
appendicitis patients who underwent surgery at Dr. SardjitoGeneral Hospital
from January 2005 to September 2009. Escherichia coli (43%) was the most common
aerobic bacteria found in children with perforated appendicitis, followed by
Pseudomonas aeruginosa (26%), Klebsiellapneumonia (11%), Streptococcus (11%),
and Proteus mirabilis (3%).The most sensitive antibiotics were imipenem, phosphomycin,
amikacin and netilmicin, followed by the 4th and the 3rd generation of cephalosporin,
amoxicillin, ampicillin, and trimethoprim/sulfamethoxazole. In addition,there
was no statistically signifcant difference in terms of resistant and sensitivity
between the 4th generation cephalosporin compared to phosphomycin, netilmicin,
or imipenem (p > 0.05). In conclusion, the most common bacteria found in
perforated appendicitis in Dr. Sardjito General Hospital is E.coli. The
administration of the 4th generation of cephalosporin might be appropriate for
the children with perforated appendicitis.
Keywords: microbiological
profle - antimicrobial susceptibility - perforated appendicitis –children –
Indonesia
Author: Andi Dwihantoro and
Rochadi
Journal Code: jpkedokterangg160176
