MEKANISME RESISTENSI ISONIAZID & MUTASI GEN KATG SER315THR (G944C) MYCOBACTERIUM TUBERCULOSIS SEBAGAI PENYEBAB TERSERINGRESISTENSI ISONIAZID

ABSTRACT: Resistance to anti-tuberculosis drugs mainly occurs due to a mutation in the genes of Mycobacterium tuberculosis. Mutations can be induced by inadequate therapeutic levels of drug, mainly due to non-compliance for taking the drug. Therefore, the use of anti-tuberculosis drugs inappropriately and irregularly can lead to mutation in the gene encoding the target of anti-tuberculosis drugs. Inadequate therapeutic levels of drug due to non-compliance of patients taking isoniazid was the most frequent causing mutations in  KatG (Ser315Thr) gene. Therefore, concluded that this mutation was the commonest cause of INH resistance and could be a potential genetic marker for predicting MDR-TB.
Penulis: Mara Imam Taufiq Siregar
Kode Jurnal: jpkedokterandd150496

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