Lower Serum Level of Anti-tetanus Toxin Antibodies in Patients with Type 2 Diabetes Mellitus
ABSTRACT: to evaluate the
serum levels of anti-tetanus toxin antibodies (anti-TTA) in patients with type
2 diabetes mellitus (DM) and in a control group. Methods: totally, 100 patients
with type 2 DM and 100 ageand sex-matched healthy individuals were enrolled to
study. The presence of type 2 DM confrmed according to the clinical and
para-clinical criteria such as fasting plasma glucose above 126 mg/dl. A
peripheral blood sample was collected from all subjects. The serum samples of
participants tested for the levels of anti-TTA by ELISA method. The serum
antitoxin concentration ≥0.1 IU/mL was considered as a protective level of
antibody. Results: the seroprotective rate in healthy group was signifcantly
higher than diabetic group (99% vs. 92%; p<0.02). The mean titer of anti-TTA
in healthy group (5.32±0.26 IU/ml) was also signifcantly higher than diabetic
patients (3.46±0.26 IU/ml; p<0.001). In diabetic men the mean titer of
anti-TTA was signifcantly higher in comparison to diabetic women (3.94±0.34
IU/ml vs 2.59±0.36 IU/ml; p<0.01). In diabetic patients the seroprotective
rate and the mean titer of anti-TTA in subjects with age >40 years was also
lower in comparison to those with age <40 years (89.23% vs 97.14%; p<0.15
and 4.57±0.38 IU/ml vs 2.86±0.32 IU/ml; P<0.002, respectively). The mean
titer of anti-TTA was signifcantly higher in patients with diabetes duration
<5 years in comparison to patients with disease duration >5 years
(3.91±0.35 IU/ml vs 2.85±0.38 IU/ml; p<0.04). Conclusion: these results
showed lower levels of anti-TTA in patients with type 2 DM, in diabetic women,
in patients aged >40 years and in diabetic patients with disease duration
>5 years .
Author: M. Nemati, M. Zarrin,
S.A. Mir-Abdollahi, M.T. Rezayati, V. Mirzaee, A. Bagheri, M. Ebrahimi, A.
Jafarzadeh
Journal Code: jpkedokterangg140271