Impulsivity and novel object recognition test of rat model for vascular cognitive impairment after antipsychotics treatment
Abstract: Vascular cognitive
impairment (VCI) is a common condition in which no standard treatment has been
approved. VCI is often accompanied by behavioral problems which require
psychiatric interventions. The common therapeutic agent used for the acute
management is antipsychotic injections. Current findings showed that atypical
antipsychotic possess better safety profile for treating behavioral problems
related to VCI compared to typical antipsychotic. In this study, we induced VCI
in Sprague Dawley rats between 6-8 weeks old using bilateral carotid communist
artery occlusion technique. The subjects were divided into 4 treatment groups:
sham, olanzapine, haloperidol, and risperidone groups. Subjects received
intramuscular injections of subsequent drugs for 3 days post VCI induction.
Impulsive behavior and object recognition were examined using cliff jumping
test and novel object recognition test. The analyses results showed that
impulsive behavior was lower in the olanzapine and haloperidol groups compared
to sham group, although it was not statistically significant. The results also
showed that there were no significant differences in the time spent exploring
old and novel objects in all groups. In conclusion, antipsychotic injection was
effective to control impulsive behavior post VCI induction.
Author: Ronny T Wirasto, Irwan
Supriyanto, Arif Prassetyo, Nunu N Madjid, Susini R Sari, Baiq R Rhadianaa,
Heru Yulianto, Nur Arfian, Nyoman Kertia
Journal Code: jpkedokterangg160178
