Impact of Frailty on the First 30 Days of Major Cardiac Events in Elderly Patients with Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention
ABSTRACT: to obtain the
proportion of frailty and the incidence of 30-day major adverse cardiovascular
events (MACE) as well as to review the impact of frailty on the prognosis of
elderly patients with coronary heart disease who underwent elective PCI.
Methods: this is a prospective cohort study to assess the frailty of elderly
patients with coronary artery disease that underwent elective PCI in Cipto
Mangunkusumo Hospital using the frailty phenotype criteria. They were
subsequently followed-up for 30 days to see whether there was any MACE developed.
Results: there were 100 elderly patients with coronary artery disease who
underwent elective PCI between September 2014 and June 2015. The mean age of
patients was 66.95 (SD 4.875) years and 69% of the patients were males. Frailty
was present in 61% of the patients. MACE were occurred in 8.19% of frail
patients and 5.12% were occurred in non-frail patients. The association between
frailty and MACE was demonstrated by the result of crude HR of 1.6 (CI 95%
0.31-8.24). In our study, the 30-day survival rate was 95% in frail patients
and 98% in non-frail patients. Conclusion: there is a 1.6-fold increased risk
of 30-day MACE in elderly frail patients undergoing elective PCI; however, it
is not statistically signifcant.
Keywords: frailty, major
adverse cardiac events, coronary artery disease, percutaneous coronary
interventions, elderly
Author: Rachmat Hamonangan,
Ika P. Wijaya, Siti Setiati, Kuntjoro Harimurti
Journal Code: jpkedokterangg160016
