Immunologic and Hormonal Effects of Prophylthiouracil Treatment Using Maintenance Dose in Graves’ Disease Patients
ABSTRACT: to assess
immunologic remission in patients with Graves’ disease following euthyroid
condition at the end of treatment with maintenance dose of PTU. Methods: this
is an intervention study using one-group pre-post design. Subjects were 25
Graves‘ disease patients visiting Metabolic Endocrinology Clinic at Dr. M.Djamil
hospital Padang and met the inclusion criteria. Patients were given PTU
treatment for 12 months. Blood samples were taken at the beginning and at the
end of treatment to determine immunological remission reflected by differences
in IL-4serum levels. Results: after maintenance therapy, we found signifcant
decrease of T3 levels (2.29±0.57 nmol/L vs. 1.87±0.34 nmol/L, p<0.05),
signifcant decrease of T4 levels (118.15±25.99 nmol/L vs. 94.15±23.76 nmol/L,
p<0.05), signifcant increase of TSH levels (0.379±0.548 vs. 0.859±0.990, p<0.05)
and signifcant decreased levels of IL-4 (12.23±5.74 vs. 3.84±0.42, p<0.05).
The IL-4 level, however, did not decrease to the normal levels. Conclusion: PTU
administration in maintenance dose can signifcantly reduce thyroid hormonal
parameter levels down to euthyroid condition, but cannot reduce immunological parameter
(IL4) to normal limit.
Author: Eva Decroli, Asman
Manaf, Syafril Syahbuddin
Journal Code: jpkedokterangg140286
