Human plasma glial fibrillary acidic protein and heat shock protein 27 concentrations in acute moderate-intensity aerobic exercise with different duration
Abstract: Glial fibrillary
acidic protein (GFAP) and heat shock protein -27 (HSP27) plasma can be used as
the parameters of exercise-induced astrocyte reactivity. The American College
of Sports Medicine (ACSM) recommends an exercise of 30 minutes or 10 minutes
duration (each performing bout accumulated toward 30 minutes). The aim of this
study was to compare GFAP and HSP27 plasma concentrations in young adults
undergoing acute moderate-intensity aerobic exercise of different durations (10
minutes vs 30 minutes).
Methods: An experimental study with pre-post design was conducted on 22
participants assigned to either 10 minutes or 30 minutes duration of single
bout exercise. Blood sampling was performed before and after the exercise. GFAP
and HSP27 plasma levels were measured with ELISA methods. Plasma GFAP and HSP27
levels before and after exercise were analyzed using paired t -test, while GFAP
and HSP27 levels after exercise between the two groups were processed using
unpaired t-test.
Results: Plasma GFAP concentration decreased significantly (0,45 ng/mL)
after 30 minutes of aerobic exercise (p<0.05). Plasma HSP27 concentration
decreased significantly (1,71 ng/mL) after 10 minutes of aerobic exercise
(p<0.05). No significant difference in plasma GFAP and HSP27 concentrations
between 10 minutes (GFAP=0.49 ng/mL; HSP27=2.09 ng/mL) and 30 minutes duration
of exercise (GFAP=0.45 ng/mL; HSP27=1,71 ng/mL).
Conclusion: Acute moderate-intensity aerobic exercise with 10- and
30-minutes duration reduces the reactivity of astrocytes indication the
increase of the synapse plasticity. The decrease in GFAP concentration occurred
after 30 minutes of exercise and the decrease in HSP27 occurred after 10
minutes of exercise. These results showed that the body responds differently to
different treatment duration in order to obtain the same effect on the body.
Author: Robert Stefanus,
Sophie Yolanda, Radiana D. Antarianto
Journal Code: jpkedokterangg160136
