Higher triglyceride serum level increases atherosclerotic index in subjects 50-70 years of age
Abstract: Atherosclerosis, the
underlying cause of heart attack, stroke and peripheral disease, is a main
cause of morbidity and mortality worldwide. Hypercholesterolemia and
hypertriglyceridemia are independent factors in the development and progression
of atherosclerosis. The atherosclerotic index (AI) is a strong indicator of
cardiovascular heart disease. The objective of this study was to determine the
relationship between lipid serum level and AI in subjects 50-70 years of age.
A study of cross-sectional design was conducted among male and female subjects
50-70 years of age. The inclusion criteria were: healthy, and capable of active
communication. The exclusion criteria were: subjects not completing the study,
currently consuming antihyperlipidemic drugs. Lipid profile comprising total
cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL),
triglycerides, and malondialdehyde (MDA), was analyzed using commercial kits.
Systolic and diastolic blood pressure and body mass index was measured in all
subjects. Atherogenic index was calculated from (total cholesterol – HDL
cholesterol) / HDL cholesterol. Multiple linear regression was used to analyze
the data.
cholesterol and triglycerides with AI (b=0.009; p=0.000 and b=0.008;
p=0.000, respectively). Triglyceride level was the most influencing factor for
AI (b=0.008; Beta=0.616; p=0.000)
Higher triglyceride levels increase AI in subjects 50-70 years of age.
Subjects with high serum triglyceride level but without symptoms of
cardiovascular disease should be examined for the development of coronary
artery blockage.
Author: Martiem Mawi,
Fransisca Chondro, Juni Chudri
Journal Code: jpkedokterangg150287
