High sensitivity C-reactive protein, left ventricular mass, and systolic function in obese adolescents
Abstract: Obesity has been
associated with structural and functional cardiac muscle defects. High
sensitivity C-reactive protein (hs-CRP) has been utilized as an independent
predictor of future cardiovascular disease.
Objective To assess for correlations between hs-CRP, left ventricular
mass, and systolic function in obese adolescents.
Methods This cross-sectional study was conducted from August 2013 to
February 2014. Subjects were obese adolescents aged 13-18 years with a body
mass index (BMI) >95th percentile, according to the 2000 Centers for Disease
Control and Prevention Growth Chart. Subjects underwent laboratory testing of
serum hs-CRP levels, as well as left ventricular mass and function measurements
by echocardiography. Descriptive analysis was performed on patients’
characteristics and correlation analysis was done by Pearson’s test with a
significance level of P<0.05.
Results Subjects were 40 obese adolescents. There was no statistically
significant correlation between hs-CRP and left ventricular mass (r=0.083;
P=0.305). There was a moderate correlation between hs-CRP with ejection
fraction (EF) (r=0.372 and P=0.009 ) and fractional shortening (FS) of the left
ventricle (r=0.420 and P=0.003).
Conclusion In obese adolescents, we find no correlation between hs-CRP
and left ventricular mass. However, hs-CRP is moderately correlated with left
ventricular EF and FS.
Author: Erling David Kaunang,
Suryani As’ad, Sarah M. Warouw, Peter Kabo
Journal Code: jpkedokterangg160040