Formula Jamu Antihipertensi and captopril are equally effective in patients with hypertension
Abstract: Hypertension is the
main cause of morbidity and mortality associated with cardiovascular diseases.
Many herbs/spices appear to have significant effects in favorably modulating
high blood pressure. A jamu formulation containing 6 plant extracts, Formula
Jamu Antihipertensi (FJA), has been described previously. This research study
aimed to evaluate the effect of FJA as antihypertensive agent in mild to
moderate hypertensive patients.
This double-blind experimental study was conducted in 40 hypertensive
patients, who were randomized into two groups. The first group was treated with
oral administration of 2 g FJA and the second group 25 mg captopril daily for 4
weeks. Systolic and diastolic blood pressure as well as liver and kidney
function were followed up every week. Independent- t test and two-way ANOVA
were used to analyze the data with a level of significance of 0.05.
The results showed that after the treatment, FJA and captopril were
capable of significantly decreasing systolic and diastolic blood pressure (p
<0.05). The decrease in systolic blood pressure between the two groups was
identical (p>0.05), while the decrease in diastolic blood pressure was
greater in the FJA group than in the captopril group (p <0.05).
From this study it may be concluded that administration of FJA for 4
weeks is equally effective as captopril in reducing systolic and diastolic
blood pressure in patients with mild and moderate hypertension. Thus, natural
plants and herbs can be our source of drugs, with fewer side effects and better
bioavailability for treatment of hypertension in the future.
Author: Atina Hussaana, Hadi
Sarosa, Ulfah Dian Indrayani, Chodidjah Chodidjah, Bagas Widiyanto, Danis
Pertiwi
Journal Code: jpkedokterangg160068