Faktor-faktor yang berhubungan dengan kadar malondialdehyde plasma pada penyandang diabetes mellitus tipe 2
Abstract: Diabetic is
associated with the risk of having lipid peroxidation causing macro and micro
vascular diseases. Malondialdehyde (MDA) is a mutagen product of lipid
peroxidation.
Objective: This research was to identify some factors associated to plasma
MDA (P-MDA) level in type 2 diabetes mellitus.
Method: Eighty two subjects were randomly recruited. Subjets were members
of Persadia, physical training club for diabetic at Mardjoeki Mahdi Hospital in
Bogor. Data of fruits, vegetables, and nuts-legumes-seeds consumption were
collected by interviewing using semi quantitative food frequency
questionnaires. Fasting blood glucose and plasma MDA were assayed using Wills
method, based on the reaction of thiobarbituric acid. Other data such as
physical training, smoking status, and diseases history were collected by
interviewing using structured questionnaires. Nutritional status data was
determined as body mass index. All data was analyzed using Odds Ratio (OR) and
logistic regression test to identify the dominant factors contributed to P-MDA
level.
Results: Factors that contribute to P-MDA level is vegetables,
nuts-legumes-seeds consumption and physical training. Consuming vegetables less
than 300 g/d and nuts-legumes-seeds less than 2.5 servings/d are associated
significantly with having high level of P-MDA (≥0.8 nmol/L), respectively OR=5
(95%CI:1.154-22.02) and OR=4.8 (95%CI:1.26-18.57). Not having physical activity
routinely is risk for having high level P-MDA (OR=1.3; 95%CI:1.12-1.45). Those
factors are associated to P-MDA level independently.
Conclusion: Vegetables and nuts-legumes-seeds consumption have a
significant contribution to P-MDA level, it is important to know further which
type and chemical content in those food that can prevent lipid peroxidation.
Penulis: Nazarina, Reviana
Christijani, Yunita Diana Sari
Kode Jurnal: jpkesmasdd130603
