Factors Influencing Bone Mineral Density in ARV-Naïve Patients at Sanglah Hospital, Bali

ABSTRACT: to evaluate factors which influence bone mineral density in ARV-naïve patients in Sanglah Hospital, Bali. Methods: a cross-sectional BMD measured by dual X-ray absorptiometry at the lumbar spine (LS) and femoral neck (FN) in 73 ARV-naïve HIV-infected patients in out patient clinic of Sanglah Hospital, consecutively, from January to June 2012. Inclusion criteria are ARV-naïve HIV-infected patients age 13-50 year old. The relationship among factors influence BMD, CD4 level, HIV RNA, HIV stage (WHO) analysed with Anova and Spearman’s correlation test. Results: this study involved 49 males and 24 females. Mean age was 33.08±8.29. Mean CD4 was 144.71±143.40 cell/mmc with the lowest CD4 is 1. Mean viral load (VL) was 272.330±282.990 copies/ml, the lowest VL ≤400 copies/ml, and the highest ≥750 000 copies/ml. Low BMD found in 32/73 (43.8%). Osteopenia and osteoporosis were diagnosed in 26/73 (35.6 %) and 6/73 (8.2%). 13 (40.6%) of the low BMD cases occured on the age group 21-30 year. Signifcant correlation found between low BMD with HIV stage (r:0.337; p<0.001). Conclusion: patients with higher HIV stage have higher risk of low BMD in ARV-naïve patient. Further study is needed to evaluate correlation of low BMD with it’s risk factors.
Key words: HIV infection, CD4 level, HIV RNA, HIV stage, bone mineral density
Author: Sri Masyeni, Susila Utama, Agus Somia, Raka Widiana, Tuti P. Merati
Journal Code: jpkedokterangg130262