Evaluation of cardiac function tests in Sudanese adult patients with sickle cell trait
Abstract: Cardiac dysfunctions
have been recognized as a common complication of sickle cell anaemia (SCA), and
together with pulmonary disorder accounts for many deaths in these patients.
However, sickle cell traits appear clinically normal, although they have
genetic abnormality. The aim of this study was to assess the effect of sickle
cell trait on cardiac prognostic markers by measuring high density lipoprotein
(HDL-C), low density lipoprotein (LDL-C), cardiac creatine kinase (CK-MB),
ultra-sensitive C reactive protein (us-CRP), total homocysteine (Hyc), and
N-terminal pro-brain natriuretic peptide (NT-pro BNP) tests in adult Sudanese
patients with sickle cell trait.
Methods: A cross-sectional study was performed in 200 healthy volunteers
as a control group and 200 diagnosed patients with sickle cell trait. It was
carried out in Khartoum Specialized Hospital, Al-Bayan Hospital, Obayed
Clinical Center and Dr. Nadir Specialized Hospital, Sudan between January 2015
and January 2016. All participants were between 20-32 years old. LDL-C, HDL-C,
CK-MB, NT-proBNP and hs-CRP concentrations were measured by Hitachi 912
full-automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer
procedure, while homocysteine level was measured by ELISA technique using
special kit.
Results: When compared to control group, the levels of LDL-C, hs-CRP and
NT-proBNP revealed significant increase in patients’ sera (p<0.001), while
Hyc and CK-MB levels were increased insignificantly in patients with SCT
(p=0.069, p=0.054 respectively). On the other hand, comparison to control
group, HDL-C showed insignificant reduction in patients (p=0.099).
Conclusion: The results suggest that sickle cell trait increased the risk
of patient-related complication secondary to cardiac dysfunction.
Author: Kamal E.A. Abdelsalam
Journal Code: jpkedokterangg160155
