Evaluating Resistance to Acetyl Salicylic Acid Using Platelet Function Test in Patients with Ischemic Stroke at Cipto Mangunkusumo Hospital
ABSTRACT: to identify the
prevalence of laboratoric ASA resistance using platelet function tests in
patients with ischemic stroke at Cipto Mangunkusumo Hospital and its associated
factors. Methods: this study was a cross-sectional study involving 50 patients
with ischemic stroke who only received ASA treatment. Evaluation of resistance
to ASA was performed using Verifynow® platelet function test. ASA resistance
was defned as ASA reaction unit (ARU) ≥550. Results: there were 7 patients with
ASA resistance. The mean age of subjects in ASA resistance group was 51.3±9.2
years; while in ASA responsive group was 57.8±9.7 years. In ASA resistance
group, there were 85.7% male patients, 57.1% active smoker and 100% subjects
with hypertension. Conclusion: the prevalence of laboratoric ASA resistance in
patients with ischemic stroke evaluated using platelet function test at Cipto
Mangunkusumo Hospital is 14%. The prevalence is more likely to occur in male patients
who were active smoker, at younger age and with comorbidity of hypertension.
Author: M. Kurniawan, Salim
Harris, Deddy Hermawan, Joedo Prihartono
Journal Code: jpkedokterangg150255
