Endothelial Dysfunction in the Young Adult: a Retrospective Cohort Study on the Effect of Low Birth Weight
ABSTRACT: to investigate the
effect of low birth weight (LBW) on endothelial function, and to determine the
role of plasma adiponectin in endothelial dysfunction by conducting flow
mediated brachial artery (FMBA) test or vasodilation response (VR) and by
measuring plasma asymmetrical dimethylarginine (ADMA) of young adults born with
LBW. Methods: in a retrospective cohort study, subjects were randomly selected
from the growth study cohort of Tanjungsari Sumedang district West Java. They
consisted of 67 LBW and 67 NBW (Normal Birth Weight) young adults. Dependent
variables were plasma adiponectin, plasma ADMA, and VR. The correlation between
plasma adiponectin and ADMA level was examined using Pearson’s correlation. Results:
the relative risk for LBW to have low brachialis artery vasodilation response
was 2.94, (95% CI:1.91-4.53), and to have low of plasma adiponectin
concentration 1.53, (95% CI: 1.07-2.18). There was a statistically signifcant
difference for all variables studied (FMBA, plasma ADMA, and plasma Adiponectin
concentrations), while simultaneous confdence interval measurements indicated
that the value of FMBA and the concentration of plasma adiponectin were
signifcantly lower, respectively p<0.001, 95% CI: -4.409-(-2.114), and
p=0.015, 95% CI: -1.083-(-0.082) in LBW compared to NBW subjects. The
correlation between plasma adiponectin concentration and plasma ADMA
concentration in LBW subjects was not signifcant. Conclusion: there is an
effect of LBW on endothelial function. LBW compared to NBW subjects have lower
VR and plasma adiponectin concentration. There may be a small role of plasma
adiponectin in endothelial dysfunction of young adults with LBW.
Author: Augustine Purnomowati,
Sri Hartini KS. Kariadi, Tri H. Achmad, Johanes C. Mose, Budhi Setianto
Journal Code: jpkedokterangg140276
