Effects of White Turmeric Infusion on the Liver Cells in Carbon Tetrachloride-Induced Mice
Abstract: The liver is an organ
that has important functions in the body. Liver damage can be caused by
oxidative stress and free radicals. White turmeric (Curcuma zedoaria L)
contains antioxidants that can be used to neutralize the effects of free
radicals. This study was conducted to determine the effect of white turmeric
infusion on histological appearance of liver cells in male mice induced by
carbon tetrachloride (CCl4).
Methods: This laboratory experimental study was conducted using male mice
(Mus musculus) with Balb/c strain. Thirty-three mice were randomly divided into
3 groups i.e.,group 1 as a control group was given standard food and drink,
group 2 was given 10% of CCl4 0.1 ml by intraperitoneal injection on the first
day and group 3 was given 10% of CCl4 0.1 mL by
ntraperitoneal injection on the first day, followed by the
administration of 50% of white turmeric infusion 0.2 mL. Kruskal-Wallis test
method was used to analyse the significant differences of the average
percentage of damaged liver cells in the group given CCl4 alone with the group
given CCl4 and white turmeric infusion and control group.
Results: The percentage of damaged liver cells between groups of mice
given CCl4 alone and the group given CCl4 followed by white turmeric infusion
were respectively(p <0.05) compared to group1.
Conclusions: Administration of white turmeric infusion gave an influence
by decreasing the percentage of damaged liver cells in CCl4-induced mice. White
turmeric can serve as an alternative antioxidants that can be used to
neutralize the effects of free radicals.
Author: Fitria Oktaviani, RB.
Soeherman Herdiningrat, Herry Yulianti
Journal Code: jpkedokterangg150302
