Effects of Duration of Breastfeeding During Infancy on Vascular Dysfunction in Adolescents
ABSTRACT: to investigate the
effect of breastfeeding duration on vascular characteristics in adolescence. Methods:
we conducted a retrospective cohort study on adolescents aged 15-18 years old.
Breastfeeding duration was inquired using a questionnaire flled by parents and
categorized into 0-<2, 2-<4, 4-<6, 6-<12, and >12 months.
Outcomes assessed were flow mediated dilation (FMD), carotid intima media
thickness (CIMT), anthropometrics. Analysis was done using linear regression
and MANOVA general linear model with cardiovascular risk factors as the
dependent variables and breastfeeding duration as the independent variable with
further adjustment for confounders. Results: 285 subjects aged 15-18 years were
enrolled. Breastfeeding duration of 4-<6 months was associated with thinner
CIMT and the effect was more prominent after adjustment for gender and
postnatal tobacco exposure (mean difference=24.28 micrometer, p=0.045). No
statistically signifcant association was found with FMD. Conclusion:
breastfeeding duration of 4-<6 months is associated with thinner IMT and
thus has a protective effect on the development of cardiovascular disease.
However the association with FMD in adolescence is less clear.
Author: Sukman Tulus Putra,
Muchtaruddin Mansyur, Sudigdo Satroasmoro
Journal Code: jpkedokterangg150258
