EFEK EKSTRAK DAUN SIRSAK (ANNONA MURICATA LINN) TERHADAP PROFIL LIPID TIKUS PUTIH JANTAN (RATTUS NORVEGICUS)
ABSTRACT: Lipid profile
effects is a risk factor for Coronary Heart Disease. Soursop leaves (Annona
muricata L) isa traditional medicine plant containing metabolic compounds that
contribute to the improvement of the lipid profile.Objective: To determine the
effects of soursop leaves extract on lipid profile (total cholesterol, LDL cholesterol,
HDLcholesterol and triglyceride).Methods: An experimental study using
randomized pre-posttest with control group design. Sample consisted of 28
maleWistar rats, were divided into four groups. The control group (K) was only
given High Fat High Cholesterol (HFHC)diet and treatment groups (P1, P2, P3)
were given a HFHC diet plus Annona muricata L extract with doses of 100, 200and
300 mg/kgBB per day for 28 days respectively. Data were analyzed by Wilcoxon
test, Kruskal-Wallis and MannWhitney.Results: The mean total cholesterol level
significantly decreased in the treatment group P1 (p = 0.028) from 60.7
mg/dl(47.6-75.3) to 45.5 mg/dl (38.4-62.4). Mean HDL cholesterol level
significantly increased in the treatment group P2(p=0.043) from 26.0 mg/dl (19.7-35.3)
to 27.9 mg/dl (18.8-38.0). The mean levels of LDL cholesterol and
triglyceridedecreased but not significantly.Conclusion: The administration of
Annona muricata L extract can decrease total cholesterol and increase
HDLcholesterol significantly.
KEYWORDS: lipid profile (total
cholesterol, LDL cholesterol, HDL cholesterol and triglyceride); HFHC diet;
Annona muricata L
Penulis: Indrawati Wurdianing,
SA Nugraheni, Zen Rahfiludin
Kode Jurnal: jpkesmasdd140412
