Efek asupan vitamin D terhadap tekanan darah sistolik tikus putih (Rattus norvegicus)
Abstract: Hypertension still
became potential life threatening disease for human life. The prevalence of
hypertension was high and tends to increase. Previous study suggested that
there was a linier rise in blood pressure at increasing distances from the
equator. More recent study indicated that vitamin D insuffi ciency may be
associated with elevated blood pressure.
Objective: To investigate the effect of vitamin D intake on blood
pressure.
Method: This was an experimental study with pre-post test group design.
The subjects were 20 male Rattus norvegicus aged 8 weeks. Subjects were divided
into 5 groups and each groups received treatment as follow: lived in dark cage
and consumed vitamin D free diet for 1 – 13 days, then moved to normal cage
(dark-light period) and given vitamin D per-oral of 0.25 μg/kg BW for 1 – 5
days. Data of systolic blood pressure was collected and analyzed with paired t
test.
Results: The absence of vitamin D in diet caused a signifi cant increase
in systolic blood pressure (p=0.01) after 7 days of treatment in dark cage.
While oral vitamin D supplementation of 0.25 μg/kg BW caused a signifi cant
decline of systolic blood pressure since the fi rst day of vitamin D
supplementation and the result appeared stronger after 4 days of treatment
(p=0.001).
Conclusion: Vitamin D intake had a strong infl uence on systolic blood
pressure
Penulis: Dessy Hermawan, Sri
Kadarsih, Sunarti ., Indwiani Astuti, Zaenal Arifin Nang Agus
Kode Jurnal: jpkesmasdd120421
