Diastolic function in patients with preeclampsia during pre- and post-partum period using tissue doppler imaging
Abstract: Prior studies have
compared the E/e’ elevation in preeclampsia patients to normal patients,
however there are no data whether this elevation persists after birth. The aim
of this study is to analyze diastolic function in preeclampsia patients during
pre- and post-partum period using E/e’ parameter measurement.
Methods: This is a prospective cohort study of pregnant women with preeclampsia
who were hospitalized and planned for pregnancy termination. Basic clinical
characteristics were obtained from all samples. Echocardiography was done
prepartum, 48-72 hours after termination, and 40-60 days postpartum. Post hoc
analysis using least significant difference method was used to compare the
results between measurements.
Results: 30 subjects were enrolled in the study. Analysis on E/e’
characteristics showed statistical difference between prepartum E/e’ and 40
days postpartum E/e’ (11.87±3.184 vs 9.43±2.529, p=0.001, CI=1.123-3.751), as
well as between 48 hours post-partum and 40 days post-partum period
(12.12±2.754 vs 9.43±2.529, p<0.001, CI=1.615-3.771). There were no
statistical differences between pre-partum E/e’ and 48 hours post-partum E/e’
(11.87±3.184 vs 12.12±2.754, p=0.633, CI=-1.345-0.832).
Conclusion: This study showed diastolic dysfunction in preeclampsia
patients persists up until a few days after birth, but resolves in time (40
days after birth) as measured by tissue doppler imaging.
Author: I B Rangga Wibhuti,
Amiliana M. Soesanto, Fahmi Shahab
Journal Code: jpkedokterangg160154
