Could CD8/38 Predict Virological Response to Antiretroviral Therapy (ART) in HIV Infected Patients?
Abstract: The success rate of
ART depends on the efficacy of the drug and the immune system’s ability to
control virus replication. Viral load examination is a standard test for ART
monitoring. Unfortunately, this test is still very limited, especially in Indonesia.
CD38 expression has been studied as a predictor for disease progression and
decreases once ART is initiated. The aim of this study was to identify the
possible usage of declining CD8/38 T-cell percentages in predicting VL. 45
subjects naïve to ART were evaluated in this observational analytic study with
a prospective design. Data collected included the medical history, physical
examination, WHO clinical staging, complete blood counts, CD4 cell count, and
plasma VL. These data then reevaluated 6 months after ART initiation. A paired
T-Test, and correlation test were used to analyze the data. Significant
differences were found in all of the laboratory parameters between pre and post
ART. There was a weak significant positive correlation between declining CD8/38
T-cell percentages and declining VL after 6 months of ART (r=0.33; p=0.026),
with r2= 0,11. Therefore despite the linear relationship, CD38 has limited
value for prediction of VL.
Author: Umi S. Intansari,
Yanri W Subronto, Yunika Puspa Dewi, Adika Zhulhi Arjana, Mohammad Juffrie,
Marsetyawan HNE Soesatyo, Budi Mulyono
Journal Code: jpkedokterangg150358
